研究業績

2023年

宮部斉重 (主要業績)

• "Alteration of microbial composition in the skin and blood in vasculitis."
  Miyata R, Miyabe C, Oki H, Motooka D, Nakamura S, Miyabe Y, Takenaka Y, Fukuya Y, Yudo K, Ishiguro N.
  Scientific Reports 15, 15317 (2023).

  • DOI: 10.1038/s41598-023-42307-7
• "Nephritis-associated plasmin receptor in the cutaneous vessels in IgA vasculitis."
  Miyabe C, Oda T, Miyata R, Miyabe Y, Ishiguro N.
  Journal of Dermatology 50, 102-103 (2023).

  • DOI: 10.1111/1346-8138.16574

自己免疫疾患グループ

• "Innate immune responses in Behçet disease and relapsing polychondritis."
  Shimizu J, Murayama MA, Mizukami Y, Arimitsu N, Takai K, Miyabe Y.
  Frontiers in Medicine 10, 1055753 (2023).

  • DOI: 10.3389/fmed.2023.1055753
• "Chemokines and chemokine receptors as promising targets in rheumatoid arthritis"
  Murayama MA, Shimizu J, Miyabe C, Yudo K, Miyabe Y.
  Frontiers in Immunology 14, 1100869 (2023).

  • DOI: 10.3389/fimmu.2023.1100869

2022年

自己免疫疾患グループ

• "Immunopathology of Behcet’s disease: an overview of the metagenomic approaches"
  Jun Shimizu, Masanori A Murayama, Yoshishige Miyabe, Noboru Suzuki
  Rheumato 2, 74-86 (2022).

  • DOI: https://doi.org/10.3390/rheumato2030010
• "Mechanical model of steady-state and inflammatory conditions in patients with relapsing polychondritis: A review. "
  Shimizu J, Suzuki N.
  Medicine (Baltimore). 101, 8, e28852 (2022).
• "Nationwide cross-sectional survey of patients with relapsing polychondritis in 2019 demonstrates reduction of airway involvement compared with that in 2009. "
  Shimizu J, Yamano Y, Kawahata K, Suzuki N.
  Scientific Reports 12, 1, 465 (2022).

2021年

宮部斉重 (主要業績)

• "Avacopan for the Treatment of ANCA-Associated Vasculitis"
  Matsuo Y, Miyabe Y.
  The New England Journal of Medicine 384(21), e81 (2021).

  • DOI: 10.1056/NEJMc2104672

自己免疫疾患グループ

• "Serum MMP3 correlated with IL1β messenger RNA expressions of peripheral blood mononuclear cells in patients with relapsing polychondritis with respiratory involvement."
  Shimizu J, Wakisaka S, Suzuki T, Suzuki N.
  ACR open rheumatology 3, 636-641 (2021).

再生医療グループ

• "Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice. "
  Arimitsu N, Mizukami Y, Shimizu J, Takai K, Suzuki T, Suzuki N.
  Molecular and Cellular Neuroscience 112, 103614 (2021).
• "Female dominance of both spatial cognitive dysfunction and neuropsychiatric symptoms in a mouse model of Alzheimer's disease."
  Murayama MA, Arimitsu N, Shimizu J, Fujiwara N, Takai K, Okada Y, Hirotsu C, Takada E, Suzuki T, Suzuki N.
  Exp. Anim. 70, 3, 398-405 (2021).
• "Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunctions with neural cell transplantation."
  Murayama MA, Arimitsu N, Shimizu J, Fujiwara N, Takai K, Okada Y, Hirotsu C, Takada E, Suzuki T, Suzuki N.
  Exp. Anim. 70, 3, 387-397 (2021).

2020年

宮部斉重 (主要業績)

• "Targeting the chemokine system in rheumatoid arthritis and vasculitis."
  Miyabe Y, Miyabe C, Iwai Y, Luster AD.
  JMA Journal 3, 182-192 (2020).
• "Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis"
  Michael BD, Bricio-Moreno L, Sorensen EW, Miyabe Y, Lian J, Solomon T, Kurt-Jones EA, Luster AD.
  Cell Reports 32, 11, 108150 (2020).

  • DOI: 10.1016/j.celrep.2020.108150

自己免疫疾患グループ

• "Elucidation of predictors of disease progression in patients with relapsing polychondritis at the onset: potential impact on patient monitoring. "
  Shimizu J, Yamano Y, Kawahata K, Suzuki N.
  BMC Rheumatology 4, 41 (2020).

2019年

宮部斉重 (主要業績)

• "Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation. "
  Miyabe Y, Miyabe C, Mani V, Mempel TR, Luster AD.
  Science Immunology 4, eaav5951 (2019).

  • DOI: 10.1126/sciimmunol.aav5951
• "Chemokines in Rheumatic Diseases and Therapeutic Implications."
  Miyabe Y, Lian J, Miyabe C, Luster AD.
  Nature Reviews Rheumatology 15, 731-746 (2019).

  • DOI: 10.1038/s41584-019-0323-6
• "Dectin-2 induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. "
  Miyabe C, Miyabe Y, Brico-Moreno L, Lian J, Rahimi R, Miura N, Ohno N, Iwakura Y, Kawakami T, Luster AD.
  The Journal of Clinical Investigation 129, 9, 3610-3624 (2019).
• "Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis"
  Miyabe C, Miyabe Y, Nagai J, Miura NN, Ohno N, Chun J, Tsuboi R, Ueda H, Miyasaka M, Miyasaka N, Nanki T.
  Arthritis Research and Therapy 21, 1, 191 (2019).

  • DOI: 10.1186/s13075-019-1973-0

自己免疫疾患グループ

• "Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease."
  Shimizu J, Kubota T, Takada E, Takai K, Fujiwara N, Arimitsu N, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.
  Clinical Rheumatology 38, 1437-45 (2019).

再生医療グループ

• "Transplantation of Human iPS Cell-Derived Neural Cells with an Artificial Nerve Conduit Leads to Cellular Retention in the Transplanted Area and Improves Motor Function in a Mouse Spinal Cord Injury Model."
  Tomochika K, Arimitsu N, Murayama MA, Hirotsu C, Nagata K, Takai K, Shimizu J, Akazawa T, Torii Y, Umehara T, Iinuma M, Niki H, Suzuki N.
  St. Marianna Med. J. 10, 27-37 (2019).
• "Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts. "
  Arimitsu N, Takai K, Fujiwara N, Shimizu J, Ueda Y, Wakisaka S, Hirotsu C, Murayama MA, Suzuki T, Suzuki N.
  Exp Neurol. 320, 112970 (2019).

2018年

宮部斉重 (主要業績)

• "Directed evolution of proteins with exceptional binding promiscuity and superior therapeutic efficacy. "
  Angelini A, Miyabe Y, Newsted D, Kwan HB, Miyabe C, Kelly RL, Jamy NM, Luster AD, Wittrup DK.
  Nature Communications 9, 1, 1461 (2018).

  • DOI: 10.1038/s41467-018-03687-x
• "CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria"
  Sorensen EW, Lian J, Ozga AJ, Miyabe Y, Ji SW, Bromley SK, Mempel TR, Luster AD.
  JCI Insight 3, 8, e98911 (2018).

  • DOI: 10.1172/jci.insight.98911
• "The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin"
  Sadik CD, Miyabe Y, Sezin T, Luster AD.
  Seminars in Immunology 37, 21-29 (2018).

  • DOI: 10.1016/j.smim.2018.03.002

自己免疫疾患グループ

• "Propionate-producing bacteria in the intestine may associate with skewed responses of IL10-producing regulatory T cells in patients with relapsing polychondritis."
  Shimizu J, Kubota T, Takada E, Takai K, Fujiwara N, Arimitsu N, Murayama MA, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.
  PLOS One 13, e0203657 (2018).
• "Relapsing polychondritis patients were divided into three subgroups: patients with respiratory involvement (R subgroup), patients with auricular involvement (A subgroup), and overlapping patients with both involvements (O subgroup), and each group had distinctive clinical characteristics."
  Shimizu J, Yamano Y, Kawahata K, Suzuki N.
  Medicine (Baltimore) 97, 42, e12837 (2018).

2017年

宮部斉重 (主要業績)

• "Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis."
  Miyabe Y, Miyabe C, Murooka TT, Kim YE, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD.
  Science Immunology 2, eaaj2195 (2017).

  • DOI: 10.1126/sciimmunol.aaj2195
• "An expanded population of pathogenic regulatory T-cells in giant cell arteritis is abrogated by IL-6 blockade therapy."
  Miyabe C, Miyabe Y, Strle K, Kim ND, Stone JH, Luster AD, and Unizony S.
  Annals of the Rheumatic Diseases 76, 898-905 (2017).
• "LTB 4 and BLT1 in inflammatory arthritis"
  Miyabe Y, Miyabe C, Luster AD.
  Seminars in Immunology 33, 52-57 (2017).

  • DOI: 10.1016/j.smim.2017.09.009

再生医療グループ

• "Neuronal cell sheet of cortical motor neuron phenotype derived from human iPS cells."
  Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Takada E, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T.
  Cell Transplant. 26, 1355-1364 (2017).

2016年

宮部斉重 (主要業績)

• "Studying Chemokine Control of Neutrophil Migration In Vivo in a Murine Model of Inflammatory Arthritis."
  Miyabe Y, Kim ND, Miyabe C, Luster AD.
  Methods in Enzymology 570, 207-31 (2016).
• "Studying Neutrophil Migration In Vivo Using Adoptive Cell Transfer. "
  Miyabe Y, Kim ND, Miyabe C, Luster AD.
  Methods in Molecular Biology 1407, 179-94 (2016).

自己免疫疾患グループ

• "Possible association of proinflammatory cytokines including IL1β and TNFα with enhanced Th17 cell differentiation in patients with Behcet's disease."
  Shimizu J, Takai K, Takada E, Fujiwara N, Arimitsu N, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.
  Clinical Rheumatology 35, 1857-63 (2016).
• "Bifidobacteria abundance-featured gut microbiota compositional change in patients with Behcet's disease."
  Shimizu J, Takai K, Takada E, Fujiwara N, Arimitsu N, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.
  PLOS One 11, e0153746 (2016).

再生医療グループ

• "Cellular transplantation as the treatment of Alzheimer's disease in mouse models. "
  Suzuki N, Shimizu J, Fujiwara N, Arimitsu N.
  J Alzheimers Dis Parkinsonism. 6, 219 (2016).
• "Human iPS cell derived neural cell sheets exhibit mature neural and extendable scaffold functions and promote recovery in injured mouse spinal cords."
  Arimitsu N, Shimizu J, Iinuma M, Umehara T, Fujiwara N, Takai K, Wakisaka S, Hirotsu C, Suzuki T, Beppu M, Niki H, Suzuki N.
  J Stem Cell Res Med. 1, 41-47 (2016).

2015年

再生医療グループ

• "Generation of retinal progenitor cell sheets which differentiate into rhodopsin positive photoreceptors from mouse iPS cell derived retinal progenitor cell clones."
  Suzuki N, Shimizu J, Hirotsu C, Takada E, Arimitsu N, Ueda Y, Fujiwara N, Suzuki T Takai K.
  Int J Ophthalmol Clin Res. 2, 1 (2015).
• "Induction of neural cells with spinal motoneuron phenotype from human iPS cells and the transplantation to totally transected spinal cords in mice. "
  Iinuma M, Umehara T, Arimitsu N, Shimizu J, Misawa H, Takai K, Fujiwara N, Fujii A, Ueda Y, Wakisaka S, Suzuki T, Hirotsu C, Beppu M, Suzuki N.
  Inflamm Regen. 35, 154-163 (2015).

2014年

宮部斉重 (主要業績)

• "Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade. "
  Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.
  Arthritis Research and Therapy 16, 461 (2014).

  • DOI: 10.1186/s13075-014-0461-

2013年

宮部斉重 (主要業績)

• "Necessity of lysophosphatidic acid receptor 1 for development of arthritis."
  Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T.
  Arthritis and Rheumatology 65, 2037-2047 (2013).

自己免疫疾患グループ

• "Skewed helper T-cell responses to IL-12 family cytokines produced by antigen-presenting cells and the genetic background in Behcet's disease. "
  Shimizu J, Kaneko F, Suzuki N.
  Genetic Research International 2013, 2013, 363859 (2013).