研究業績

宮部斉重 (主要業績)

2023年

• "Alteration of microbial composition in the skin and blood in vasculitis."
  Miyata R, Miyabe C, Oki H, Motooka D, Nakamura S, Miyabe Y, Takenaka Y, Fukuya Y, Yudo K, Ishiguro N.
  Scientific Reports 15, 15317 (2023).

  • DOI: 10.1038/s41598-023-42307-7
• "Nephritis-associated plasmin receptor in the cutaneous vessels in IgA vasculitis."
  Miyabe C, Oda T, Miyata R, Miyabe Y, Ishiguro N.
  Journal of Dermatology 50, 102-103 (2023).

  • DOI: 10.1111/1346-8138.16574

2021年

• "Avacopan for the Treatment of ANCA-Associated Vasculitis"
  Matsuo Y, Miyabe Y.
  The New England Journal of Medicine 384(21), e81 (2021).

  • DOI: 10.1056/NEJMc2104672

2020年

• "Targeting the chemokine system in rheumatoid arthritis and vasculitis."
  Miyabe Y, Miyabe C, Iwai Y, Luster AD.
  JMA Journal 3, 182-192 (2020).
• "Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis"
  Michael BD, Bricio-Moreno L, Sorensen EW, Miyabe Y, Lian J, Solomon T, Kurt-Jones EA, Luster AD.
  Cell Reports 32, 11, 108150 (2020).

  • DOI: 10.1016/j.celrep.2020.108150

2019年

• "Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation. "
  Miyabe Y, Miyabe C, Mani V, Mempel TR, Luster AD.
  Science Immunology 4, eaav5951 (2019).

  • DOI: 10.1126/sciimmunol.aav5951
• "Chemokines in Rheumatic Diseases and Therapeutic Implications."
  Miyabe Y, Lian J, Miyabe C, Luster AD.
  Nature Reviews Rheumatology 15, 731-746 (2019).

  • DOI: 10.1038/s41584-019-0323-6
• "Dectin-2 induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. "
  Miyabe C, Miyabe Y, Brico-Moreno L, Lian J, Rahimi R, Miura N, Ohno N, Iwakura Y, Kawakami T, Luster AD.
  The Journal of Clinical Investigation 129, 9, 3610-3624 (2019).
• "Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis"
  Miyabe C, Miyabe Y, Nagai J, Miura NN, Ohno N, Chun J, Tsuboi R, Ueda H, Miyasaka M, Miyasaka N, Nanki T.
  Arthritis Research and Therapy 21, 1, 191 (2019).

  • DOI: 10.1186/s13075-019-1973-0

2018年

• "Directed evolution of proteins with exceptional binding promiscuity and superior therapeutic efficacy. "
  Angelini A, Miyabe Y, Newsted D, Kwan HB, Miyabe C, Kelly RL, Jamy NM, Luster AD, Wittrup DK.
  Nature Communications 9, 1, 1461 (2018).

  • DOI: 10.1038/s41467-018-03687-x
• "CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria"
  Sorensen EW, Lian J, Ozga AJ, Miyabe Y, Ji SW, Bromley SK, Mempel TR, Luster AD.
  JCI Insight 3, 8, e98911 (2018).

  • DOI: 10.1172/jci.insight.98911
• "The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin"
  Sadik CD, Miyabe Y, Sezin T, Luster AD.
  Seminars in Immunology 37, 21-29 (2018).

  • DOI: 10.1016/j.smim.2018.03.002

2017年

• "Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis."
  Miyabe Y, Miyabe C, Murooka TT, Kim YE, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD.
  Science Immunology 2, eaaj2195 (2017).

  • DOI: 10.1126/sciimmunol.aaj2195
• "An expanded population of pathogenic regulatory T-cells in giant cell arteritis is abrogated by IL-6 blockade therapy."
  Miyabe C, Miyabe Y, Strle K, Kim ND, Stone JH, Luster AD, and Unizony S.
  Annals of the Rheumatic Diseases 76, 898-905 (2017).
• "LTB 4 and BLT1 in inflammatory arthritis"
  Miyabe Y, Miyabe C, Luster AD.
  Seminars in Immunology 33, 52-57 (2017).

  • DOI: 10.1016/j.smim.2017.09.009

2016年

• "Studying Chemokine Control of Neutrophil Migration In Vivo in a Murine Model of Inflammatory Arthritis."
  Miyabe Y, Kim ND, Miyabe C, Luster AD.
  Methods in Enzymology 570, 207-31 (2016).
• "Studying Neutrophil Migration In Vivo Using Adoptive Cell Transfer. "
  Miyabe Y, Kim ND, Miyabe C, Luster AD.
  Methods in Molecular Biology 1407, 179-94 (2016).

2014年

• "Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade. "
  Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.
  Arthritis Research and Therapy 16, 461 (2014).

  • DOI: 10.1186/s13075-014-0461-

2013年

• "Necessity of lysophosphatidic acid receptor 1 for development of arthritis."
  Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T.
  Arthritis and Rheumatology 65, 2037-2047 (2013).